Sodium hydride → HCID 86087174, compound

Participants

Reaction Steps

6-(Methyloxy)-3-octyl-2-phenyl-1-naphthalenol (193) (0.60 g, 1.66 mmol) was treated with NaH in DMF followed by addition of 4-fluorobenzaldehyde to give 0.72 g (93%) of the title compound (194) as a yellow oil. 1H NMR (400 MHz, CDCl3): δ 0.84 (t, J=7.0 Hz, 3H), 1.05-1.30 (m, 10H), 1.40-1.50 (m, 2H), 2.54 (t, J=7.9 Hz, 2H), 3.94 (s, 3H), 6.67 (d, J=8.4 Hz, 2H), 7.03-7.14 (m, 3H), 7.16-7.26 (m, 4H), 7.56-7.64 (m, 3H), 7.67 (d, J=9.1 Hz, 1H), 9.79 (s, 1H). LCMS (APCI): m/z 467 (M+H)+.

Provenance & Evidence