Triethyl 2-phosphonopropionate → HCID 68534712, compound

Participants

Reaction Steps

As described above, 4-(6-Methoxy-3-methyl-2-phenyl-naphthalen-1-yloxy)-benzaldehyde (8) (0.21 g, 0.570 mmol), triethyl 2-phosphonopropionate (0.183 mL, 0.855 mmol), 1.6 M nBuLi (0.57 mL, 0.912 mmol) in dry THF (8 mL) afforded 0.2 g (78%) of the title compound (219) as oil. 1H NMR (400 MHz, d-CDCl3): δ 1.31 (t, J=7.1 Hz, 3H), 2.04 (s, 3H), 2.24 (s, 3H), 3.93 (s, 3H), 4.20-4.25 (m, 2H), 6.59 (d, J=8.8 Hz, 2H), 7.03-7.06 (m, 1H), 7.11-7.16 (m, 5H), 7.21-7.25 (m, 3H), 7.55 (d, J=9.7 Hz, 2H), 7.75 (d, J=9.1 Hz, 1H).

Provenance & Evidence