Tetrahydrofuran → HCID 68536384, compound

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Reaction Steps

As described above, 3-[4-(6-Methoxy-3-methyl-2-phenyl-naphthalen-1-yloxy)-phenyl]-2-methylacrylic acid ethyl ester (219) (0.189 g, 0.418 mmol), THF (3 mL), EtOH (3 mL) and 1 N NaOH (4 mL) afforded 0.156 g (88%) of title compound (220) as a solid. 1H NMR (400 MHz, d-CDCl3): δ 2.07 (s, 3H), 2.24 (s, 3H), 3.93 (s, 3H), 6.61 (d, J=8.8 Hz, 2H), 7.04 (dd, J1=2.5 Hz, J2=9.2 Hz, 1H), 7.12-7.14 (m, 3H), 7.17-7.21 (m, 2H), 7.23-7.27 (m, 3H), 7.56 (s, 1H), 7.64 (s, 1H), 7.74 (d, J=9.1 Hz, 1H).

Provenance & Evidence