HCID 68536290, compound → HCID 11669440, compound

HRID 1992997Notes

Reaction equation

HRID 1992997 reaction equation
[CH3:1][C:2]1[C:3]([C:34]2[CH:39]=[CH:38][C:37]([O:40]CC3C=CC=CC=3)=[CH:36][CH:35]=2)=[C:4]([O:22][C:23]2[CH:28]=[CH:27][C:26](/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32])=[CH:25][CH:24]=2)[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][C:8]([O:14]CC1C=CC=CC=1)=[CH:7][CH:6]=2>C(Cl)(Cl)Cl.CO>[OH:14][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[C:4]([O:22][C:23]1[CH:24]=[CH:25][C:26]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[CH:27][CH:28]=1)=[C:3]([C:34]1[CH:35]=[CH:36][C:37]([OH:40])=[CH:38][CH:39]=1)[C:2]([CH3:1])=[C:11]2[O:12][CH3:13]

Participants

3

Reactant 1

HCID 68536290HCID 68536290, compound

Product 1

HCID 11669440HCID 11669440, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Synthesized in manner similar to that employed for Example 46 (Step 8) using (2E)-3-{4-[(3-methyl-4-(methyloxy)-6-[(phenylmethyl)oxy]-2-{4-[(phenylmethyl)oxy]phenyl}-1-naphthalenyl)oxy]phenyl}-2-propenoic acid (258). 1H NMR (CD3OD, 400 MHz) δ 7.61 (d, J=9.1 Hz, 1H), 7.35 (d, J=2.4 Hz, 1H), 6.94-6.89 (m, 5H), 6.66 (d, J=8.4 Hz, 2H), 6.42 (d, J=8.4 Hz, 2H), 3.88 (s, 3H), 2.77-2.73 (m, 2H), 2.38 (bs, 2H), 2.12 (s, 3H). LRMS (ES−) m/z 443 (M−1)−. TLC (90:10; CHCl3/MeOH): Rf=0.07.

Workup

  1. customSynthesized in manner similar to

Sources & evidence

ORD record
ord-81395271186849e6b796b08dc6341151
Source dataset
uspto-grants-2010_01
Patent number
US07649093B2

Reaction notes

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