HCID 11632964, compound → HCID 11697318, compound

HRID 1993001Notes

Reaction equation

HRID 1993001 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([CH3:31])[C:8]([C:24]3[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=3)=[C:9]2[O:12][C:13]2[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.CO>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([CH3:31])[C:8]([C:24]3[CH:25]=[CH:26][C:27]([OH:30])=[CH:28][CH:29]=3)=[C:9]2[O:12][C:13]2[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][CH:18]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 11632964HCID 11632964, compound

Product 1

HCID 11697318HCID 11697318, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Synthesized in a manner similar to Example 47 using (2E)-3-(4-{[7-hydroxy-2-(4-hydroxyphenyl)-3-methyl-1-naphthalenyl]oxy}phenyl)-2-propenoic acid (267). 1H NMR (CD3OD, 400 MHz) δ 7.68 (d, J=9.5 Hz, 1H), 7.54 (s, 1H), 7.03-7.00 (m, 2H), 6.95-6.91 (m, 4H), 6.67 (d, J=8.4 Hz, 2H), 6.45 (d, J=8.4 Hz, 2H), 2.78-2.74 (m, 2H), 2.49-2.47 (m, 2H), 2.18 (s, 3H). LRMS (ESI) m/z 413 (M−1)−. TLC (90:10; CHCl3/MeOH): Rf=0.21.

Sources & evidence

ORD record
ord-c31a272aeadf4d9e856d561594992ecf
Source dataset
uspto-grants-2010_01
Patent number
US07649093B2

Reaction notes

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