HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993050Generated: October 30, 2026
Propionic Acid → 3-[2-Methyl-4-(2-methyl-benzyloxy)-phenyl]-hex-4-enoic acid ethyl ester
https://huagongshe.com/reaction/1993050
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | Triethyl orthoacetate | HCID 66221 | — |
| Reactant | 4-[2-Methyl-4-(2-methyl-benzyloxy)-phenyl]-but-3-en-2-ol | HCID 68676091 | — |
| Product | 3-[2-Methyl-4-(2-methyl-benzyloxy)-phenyl]-hex-4-enoic acid ethyl ester | HCID 68675521 | 39% |
Reaction Steps
Propionic acid (cat.) was added to a solution of 31.5 (69 mg, 0.24 mmol) in 1,1,1-triethoxy-ethane (440 μL, 2.4 mmol). The reaction was stirred at 105° C. overnight. The solvent was removed under reduced pressure and the resulting residue was purified via radial chromatography (5% ethyl acetate in hexanes) to yield 33 mg (39%) of 3-[2-Methyl-4-(2-methyl-benzyloxy)-phenyl]-hex-4-enoic acid ethyl ester (31.6). LC/MSD m/e: 375.0 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07649110B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-ed10e0c8c4194af685487662f7c20384 |
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| Source note | uspto-grants-2010_01 |
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