HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-fluorophenyl)-3-(4-hydroxyphenyl)-acrylate → 3-(4-Fluorophenyl)-3-(4-hydroxyphenyl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-fluorophenyl)-3-(4-hydroxyphenyl)-acrylate | HCID 68674988 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(4-Fluorophenyl)-3-(4-hydroxyphenyl)-propionic acid ethyl ester | HCID 57835725 | 90.3% |
Reaction Steps
A solution of 45.1 (385 mg) in ethanol (12 mL) and ethyl acetate (10 mL) was stirred with 10% Pd—C (50 mg) under a hydrogen atmosphere at room temperature for 3 h. The reaction mixture was filtered and concentrated to provide 45.2 (350 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07649110B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-6eb9b0060674435d939bed752e84c406 |
| Source note | uspto-grants-2010_01 |