HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Ethyl 3-(4-(3-iodobenzyloxy)phenyl)-3-(4-fluorophenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Iodobenzyl bromide | HCID 2759361 | — |
| Reactant | 3-(4-Fluorophenyl)-3-(4-hydroxyphenyl)-propionic acid ethyl ester | HCID 57835725 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 3-(4-(3-iodobenzyloxy)phenyl)-3-(4-fluorophenyl)propanoate | HCID 59132743 | — |
Reaction Steps
Cs2CO3 (4.89 g 15 mmol) and 1-(bromomethyl)-3-iodobenzene (4.45 g, 15 mmol) were added successively to a dry DMF (20 mL) solution of 45.2 (2.88 g, 10 mmol). The reaction mixture was stirred at room temperature overnight, diluted with ethyl acetate (200 mL), washed with water (100 mL×2) and brine (100 mL), and dried over Na2SO4. The solvent was removed under vacuum and the residue was purified by flash chromatography to give compound 47.1 as a colorless oil. MS ESI (pos.) m/e: 505.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07649110B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-6b144228ea3b404f95a2b7706815c477 |
| Source note | uspto-grants-2010_01 |