HCID 86600758, compound → HCID 72525351, compound

HRID 1993106Notes

Reaction equation

C(OP(CO[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][CH:28]2[CH:34]([OH:35])[CH2:33][N:32]([CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[N:31]([CH2:43][C:44]3[CH:49]=[CH:48][C:47]([OH:50])=[C:46]([O:51][CH3:52])[CH:45]=3)[C:30](=[O:53])[N:29]2[CH2:54][C:55]2[CH:60]=[CH:59][C:58]([OH:61])=[C:57]([O:62][CH3:63])[CH:56]=2)[CH:22]=1)(=O)OCC1C=CC=CC=1)C1C=CC=CC=1.[CH2:64]([O:71][P:72]([CH2:82][O:83]C1C=CC=CC=1CC1C(O)CN(CC2C=CC=CC=2)N(CC2C=CC(O)=C(OC)C=2)C(=O)N1CC1C=CC(O)=C(OC)C=1)(=[O:81])[O:73][CH2:74][C:75]1[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=1)[C:65]1[CH:70]=[CH:69][CH:68]=[CH:67][CH:66]=1>>[CH2:74]([O:73][P:72]([CH2:82][O:83][C:26]1[CH:21]=[CH:22][C:23]([CH2:27][CH:28]2[CH:34]([OH:35])[CH2:33][N:32]([CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[N:31]([CH2:43][C:44]3[CH:49]=[CH:48][C:47]([OH:50])=[C:46]([O:51][CH3:52])[CH:45]=3)[C:30](=[O:53])[N:29]2[CH2:54][C:55]2[CH:60]=[CH:59][C:58]([OH:61])=[C:57]([O:62][CH3:63])[CH:56]=2)=[CH:24][CH:25]=1)(=[O:81])[O:71][CH2:64][C:65]1[CH:70]=[CH:69][CH:68]=[CH:67][CH:66]=1)[C:75]1[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=1

Participants

Reactant 2

HCID 86600758HCID 86600758, compound

HCID 86600759HCID 86600759, compound

Product 1

HCID 72525351HCID 72525351, compound

Procedure

The meta substituted analog {3-[1-Benzyl-6-hydroxy-2,4-bis-(4-hydroxy-3-methoxy-benzyl)-3-oxo-[1,2,4]triazepan-5-ylmethyl]-phenoxymethyl}-phosphonic acid dibenzyl ester or the ortho analog, {2-[1-Benzyl-6-hydroxy-2,4-bis-(4-hydroxy-3-methoxy-benzyl)-3-oxo-[1,2,4]triazepan-5-ylmethyl]-phenoxymethyl}-phosphonic acid dibenzyl ester, are prepared using the same methods except replacing the p-benzyloxyepoxide 13 with the meta- and ortho-substituted benzyloxy epoxides, 11 and 8, respectively.

Sources & evidence

ORD record: ord-aead13ba14f3433986d01c3e646316af
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07649015B2

Reaction notes

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