Bicarbonate Ion → 2-[4-(3-Aminopyrrolidin-1-yl)-7-methylquinazolin-2-yl]phenol

HRID 199318Notes

Reaction equation

[Cl:37][CH2:38][Cl:39].[Na+:36].[O-:32][C:33]([OH:34])=[O:35].[OH:1][c:2]1[c:3](-[c:8]2[n:9][c:10]3[cH:11][c:12]([CH3:31])[cH:13][cH:14][c:15]3[c:16]([N:18]3[CH2:19][CH:20]([NH:23][C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:21][CH2:22]3)[n:17]2)[cH:4][cH:5][cH:6][cH:7]1>>[OH:1][c:2]1[c:3](-[c:8]2[n:9][c:10]3[cH:11][c:12]([CH3:31])[cH:13][cH:14][c:15]3[c:16]([N:18]3[CH2:19][CH:20]([NH2:23])[CH2:21][CH2:22]3)[n:17]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

Reactant 4

HCID 769Bicarbonate Ion

HCID 923Sodium ion

HCID 6344Dichloromethane

HCID 136121483tert-butyl N-[1-[2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl]pyrrolidin-3-yl]carbamate

Product 1

HCID 1361215132-[4-(3-Aminopyrrolidin-1-yl)-7-methylquinazolin-2-yl]phenol

Sources & evidence

ORD record: ord-d6d33ce3824b400ab68108068bf1b860
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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