Sodium amide → HCID 17967039, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 30 g of 3-(trifluoromethyl)-phenylacetonitrile and 14.4 g of sodium amide in 400 ml of toluene is left with stirring at AT for 5 minutes, 66 ml of bromoacetaldehyde diethyl acetal are added and then the mixture is heated at 60° C. for 3 hours. It is concentrated under vacuum, the residue is taken up with water and extracted with ether, the organic phase is dried over Na2SO4 and the solvent is evaporated under vacuum. The residue is chromatographed on silica gel H, eluting with a DCM/AcOEt (100/5; v/v) mixture. This gives 26 g of the expected product.

Provenance & Evidence