HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(Phenylmethyl)-4-[3-(trifluoromethyl)phenyl]-4-piperidinemethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 67541581 | HCID 67541581 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Phenylmethyl)-4-[3-(trifluoromethyl)phenyl]-4-piperidinemethanamine | HCID 17967007 | — |
Reaction Steps
A mixture of 1.5 g of the compound obtained in step C of Preparation 1.4, 0.15 g of Raney® nickel and 5 ml of ammonia in 20 ml of MeOH is hydrogenated overnight at AT and under atmospheric pressure. The catalyst is filtered off and the filtrate is concentrated under vacuum. This gives 1.45 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652011B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-71ec24a7dc974e398a21c2fd42a5f10e |
| Source note | uspto-grants-2010_01 |