Benzyl Bromide → N-Benzylnormechlorethamine

Participants

Reaction Steps

Using an ice bath, a mixture of 150 g of N,N-bis(2-chloroethyl)amine hydrochloride and 100 ml of benzyl bromide in 1000 ml of DMF is cooled and then 120 ml of triethylamine are added dropwise and the mixture is left overnight with stirring at AT. The reaction mixture is concentrated under vacuum, the residue is taken up with water and extracted 3 times with ether, the organic phases are dried over Na2SO4 and the solvent is evaporated under vacuum. This gives 113 g of the expected product.

Provenance & Evidence