HCID 23505601, compound → HCID 23505668, compound

Participants

Reaction Steps

A mixture of 1-ethyl-6,7-ethylenedioxy-4-phenyl-3,4-dihydroquinazolin-2(1H)-thione (77 mg, 0.24 mmol) and MnO2 (180 mg, 2.07 mmol) in 5 mL of CHCl3 was stirred at rt for 3 days. The solids were filtered off and the solution concentrated in vacuo. The crude residue was subjected to flash column chromatography eluting with EtOAc:hexane to give the title compound (35 mg, 46%). 1H NMR (CDCl3): 7.72 (dd, 2H), 7.53-7.49 (m, 3H), 7.38 (s, 1H), 7.09 (3, 1H), 4.90 (m, 2H), 4.48-4.30 (m, 4H), 1.55 (t, 3H).

Provenance & Evidence