HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1,3-Benzodioxol-5-yl)-1-isopropylurea → 1-Isopropyl-6,7-methylenedioxy-4-(3,4-ethylenedioxi-phenyl)-3,4-dihydroquinazolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1,3-Benzodioxol-5-yl)-1-isopropylurea | HCID 100555 | — |
| Reactant | 2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde | HCID 248127 | — |
| Product | 1-Isopropyl-6,7-methylenedioxy-4-(3,4-ethylenedioxi-phenyl)-3,4-dihydroquinazolin-2(1H)-one | HCID 12150173 | 32% |
Reaction Steps
This compound was synthesized from N-isopropyl-N-[3,4-(methylenedioxy)-phenyl]urea (240 mg) and 1,4-benzodioxan-6-carboxaldehyde (181 mg) by the procedure described in example 10 in 32% yield, mp: 185-187° C. 1H NMR (CDCl3): 6.86-6.75 (m, 3H), 6.67 (s, 1H), 6.30 (s, 1H), 5.91 (s, 1H), 6.89 (s, 1H), 5.18 (s, 1H), 4.99 (br s, 1H), 4.44 (m, 2H), 4.25 (s, 4H), 1.56 (d, J=6.8, 3H), 1.55 (d, J=6.8, 3H). Anal. calcd. for C20H20N2O5.(½)H2O: C, 63.65; H, 5.61; N, 7.42. Found: C, 63.37; H, 5.34: N, 7.07.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652006B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-cbfa6f911d08463695aed8bdc3ae8eae |
| Source note | uspto-grants-2010_01 |