2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 12150175, compound

HRID 1993314Notes

Reaction equation

HRID 1993314 reaction equation
[CH:1]([N:4]([C:8]1[CH:13]=[CH:12][C:11]2[O:14][CH2:15][CH2:16][O:17][C:10]=2[CH:9]=1)[C:5]([NH2:7])=[O:6])([CH3:3])[CH3:2].[O:18]1[C:23]2[CH:24]=[CH:25][C:26]([CH:28]=O)=[CH:27][C:22]=2[O:21][CH2:20][CH2:19]1>>[CH:1]([N:4]1[C:8]2[C:13](=[CH:12][C:11]3[O:14][CH2:15][CH2:16][O:17][C:10]=3[CH:9]=2)[CH:28]([C:26]2[CH:25]=[CH:24][C:23]3[O:18][CH2:19][CH2:20][O:21][C:22]=3[CH:27]=2)[NH:7][C:5]1=[O:6])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 23505689HCID 23505689, compound

Product 1

HCID 12150175HCID 12150175, compoundYield 14%

Procedure

This compound was synthesized from N-isopropyl-N-[3,4-(ethylenedioxy)-phenyl]urea (132 mg) and 1,4-benzodioxan-6-carboxaldehyde (113 mg) by the procedure described in example 10 in 14% yield,. mp: 92-95° C. 1H NMR (CDCl3): 6.85-6.76 (m, 3H), 6.62 (s, 1H), 6.32 (s, 1H), 5.20 (s, 1H), 4.99 (s, 1H), 4.46 (m, 1H), 4.24 (s, 4H), 4.23-4.17 (m, 4H), 1.56 (d, J=6.9, 3H), 1.54 (d, J=6.9, 3H).

Sources & evidence

ORD record
ord-329222ec822a47f3b4e8a4c5901abf21
Source dataset
uspto-grants-2010_01
Patent number
US07652006B2

Reaction notes

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