Hydrochloric Acid → HCID 23505674, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(3,4-methylenedioxyphenyl)-6,7-methylenedioxy-1(2H)-phthalazinone (133 mg, 0.43 mmol), 1-(2-bromoethyl)imidazole hydrogen bromide (439 mg, 1.72 mmol), and K2CO3 (415 mg, 3.0 mmol) in DMF (10 mL) was stirred for 5 h at 70° C. The mixture was cooled, and 2N HCl and EtOAc were added to the mixture. The acidic aqueous layer was separated, made alkaline with 5% K2CO3 solution, and extracted with EtOAc. The extract was washed with brine, dried and concentrated under reduced pressure. The residual solid were purified by chromatography on silica gel with CHCl3-MeOH (20:1) to afford the product as a white solid (27 mg, 16%). 300 MHz 1H-NMR (CDCl3): δ 7.78 (s, 1H), 7.37 (s, 1H), 7.04-6.86 (m, 5H), 6.13 (s, 2H), 6.03 (s, 2H), 4.58 (m, 2H), 4.45 (m, 2H).

Provenance & Evidence