HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993343Generated: October 30, 2026
Hydrogen Bromide → 2-benzyl-5-(3-fluoro-4-hydroxyphenyl)-3-methyl-3H-pyrimidin-4-one
https://huagongshe.com/reaction/1993343
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-benzyl-5-(3-fluoro-4-methoxyphenyl)-3-methyl-3H-pyrimidin-4-one | HCID 58828849 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-benzyl-5-(3-fluoro-4-hydroxyphenyl)-3-methyl-3H-pyrimidin-4-one | HCID 58828869 | — |
Reaction Steps
HBr (40%, ACS reagent grade) was added to 2-benzyl-5-(3-fluoro-4-methoxyphenyl)-3-methyl-3H-pyrimidin-4-one (Step 4, 9 g, 26 mmol) in HOAc (90 mL). The reaction was heated to 130° C. and monitored by HPLC. After 3 h, the reaction was cooled to RT and the solid was collected by filtration. The solid was washed with H2O and Et2O and dried to afford the title compound as a yellow solid. MS (ESI pos. ion) m/z: 311.1. Calc'd for C18H15FN2O2: 310.11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07652009B2 |
|---|
| Source dataset | uspto-grants-2010_01 |
|---|
| ORD ID | ord-6a3154c5a0ad4342a3c983828a3626db |
|---|
| Source note | uspto-grants-2010_01 |
|---|
