HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7-dimethoxyquinoline → 4-[2-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenoxy]-6,7-dimethoxy-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| Reactant | 2-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol | HCID 136070705 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-[2-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenoxy]-6,7-dimethoxy-quinoline | HCID 11857508 | — |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
A mixture of 4-chloro-6,7-dimethoxy-quinoline (0.4 g, 1.79 mmol), 2-fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol (Step 2, 0.50 g, 1.79 mmol) and DMAP (0.22 g, 1.79 mmol) in 6 mL of toluene (in microwave tube) was heated in a microwave (Personal Chemistry, Emrys Optimizer) at 180° C. for 1 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652009B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-9f9b7c037ca44077b586972fead6cf5d |
| Source note | uspto-grants-2010_01 |