HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993370Generated: October 29, 2026
4-Aminophenol → Methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylate
https://huagongshe.com/reaction/1993370
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Dimethyl itaconate | HCID 69240 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylate | HCID 2883518 | — |
Reaction Steps
A mixture of 4-amino-phenol (3 g, 0.027 mol) and 2-methylene-succinic acid dimethyl ester (4.35 g, 0.027 mol) was heated to 110° C. for 16 h. The dark brown glass was dissolved in EtOAc and purified by silica gel chromatography (20% EtOAc/hexane to EtOAC) to give the title compound as an orange oil. MS (ESI pos. ion) m/z: 236.2 (M+H). Calc'd Exact Mass for C12H13NO4: 235.24.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07652009B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-3c5013ddfda1419890abab43a6d3cfd5 |
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| Source note | uspto-grants-2010_01 |
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