2,3-Dimethyl-p-anisaldehyde → 6-[4-(4-Methoxy-2,3-dimethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one

HRID 1993409Notes

Reaction equation

HRID 1993409 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:14][C:15]1[C:22]([CH3:23])=[C:21]([O:24][CH3:25])[CH:20]=[CH:19][C:16]=1[CH:17]=O>>[CH3:25][O:24][C:21]1[CH:20]=[CH:19][C:16]([CH2:17][N:4]2[CH2:5][CH2:6][N:1]([C:7]3[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=3)[CH2:2][CH2:3]2)=[C:15]([CH3:14])[C:22]=1[CH3:23]

Participants

3

Reactant 2

HCID 5960582,3-Dimethyl-p-anisaldehydeHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2×

Product 1

HCID 1361025866-[4-(4-Methoxy-2,3-dimethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one

Procedure

6-[4-(4-Methoxy-2,3-dimethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure A from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2,3-dimethylanisaldehyde. Mass spectrum (ES) MH+=329.

Sources & evidence

ORD record
ord-f57a4a3d9b7e47cab6e176185625a40b
Source dataset
uspto-grants-2010_01
Patent number
US07652013B2

Reaction notes

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