o-(Trifluoromethyl)benzaldehyde → HCID 135879447, compound

HRID 1993412Notes

Reaction equation

HRID 1993412 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:14][C:15]([F:25])([F:24])[C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH:18]=O>>[F:14][C:15]([F:24])([F:25])[C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18][N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 123067o-(Trifluoromethyl)benzaldehydeHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2×

Product 1

HCID 135879447HCID 135879447, compound

Procedure

6-[4-(2-Trifluoromethyl-benzyl)-piperazin-1-yl]-3H -pyrimidin-4-one was prepared using Procedure A from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2-(trifluoromethyl)benzaldehyde. Mass spectrum (ES) MH+=339.

Sources & evidence

ORD record
ord-49f9bf5524d84d6bb3491b3ab6217d68
Source dataset
uspto-grants-2010_01
Patent number
US07652013B2

Reaction notes

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