Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993413Generated: October 26, 2026

2,5-Bis(trifluoromethyl)benzaldehyde → 6-[4-(2,5-Bis-trifluoromethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one

https://huagongshe.com/reaction/1993413

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-Bis(trifluoromethyl)benzaldehydeHCID 2737807—
Reactant6-piperazin-1-yl-3H-pyrimidin-4-oneHCID 136102540—
Product6-[4-(2,5-Bis-trifluoromethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-oneHCID 136102543—

Reaction Steps

6-[4-(2,5-Bis-trifluoromethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure A from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2,5-bis(trifluoromethyl)benzaldehyde. Mass spectrum (ES) MH+=407.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07652013B2
Source datasetuspto-grants-2010_01
ORD IDord-1130c77bf8b6483faeaebfff5e3432e1
Source noteuspto-grants-2010_01