m-Formylbenzonitrile → HCID 136102552, compound

HRID 1993414Notes

Reaction equation

HRID 1993414 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:14]([C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[CH:19]=O)#[N:15]>>[O:13]=[C:9]1[NH:10][CH:11]=[N:12][C:7]([N:1]2[CH2:6][CH2:5][N:4]([CH2:19][C:18]3[CH:17]=[C:16]([CH:23]=[CH:22][CH:21]=3)[C:14]#[N:15])[CH2:3][CH2:2]2)=[CH:8]1

Participants

3

Reactant 2

HCID 90670m-FormylbenzonitrileHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2×

Product 1

HCID 136102552HCID 136102552, compound

Procedure

3-[4-(6-Oxo-1,6-dihydro-pyrimidin-4-yl)-piperazin-1-ylmethyl]-benzonitrile was prepared using Procedure A from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 3-cyanobenzaldehyde. Mass spectrum (ES) MH+=296.

Sources & evidence

ORD record
ord-498983b620494d7daf7770a6b2e4e7d4
Source dataset
uspto-grants-2010_01
Patent number
US07652013B2

Reaction notes

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