2-Fluoro-5-formylbenzonitrile → HCID 136102537, compound

HRID 1993415Notes

Reaction equation

HRID 1993415 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:14][C:15]1[CH:22]=[CH:21][C:20]([CH:23]=O)=[CH:19][C:16]=1[C:17]#[N:18]>>[F:14][C:15]1[CH:22]=[CH:21][C:20]([CH2:23][N:4]2[CH2:5][CH2:6][N:1]([C:7]3[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=3)[CH2:2][CH2:3]2)=[CH:19][C:16]=1[C:17]#[N:18]

Participants

3

Reactant 2

HCID 27695822-Fluoro-5-formylbenzonitrileHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2×

Product 1

HCID 136102537HCID 136102537, compound

Procedure

2-Fluoro-5-[4-(6-oxo-1,6-dihydro-pyrimidin-4-yl) -piperazin-1-ylmethyl]-benzonitrile was prepared using Procedure A from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2-fluoro-5-formylbenzonitrile. Mass spectrum (ES) MH+=314.

Sources & evidence

ORD record
ord-681d1668b1e24193bc3f33d02ca0de5f
Source dataset
uspto-grants-2010_01
Patent number
US07652013B2

Reaction notes

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