3,4-Difluorobenzaldehyde → HCID 136102563, compound

HRID 1993425Notes

Reaction equation

HRID 1993425 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][C:22]=1[F:23])[CH:18]=O>>[F:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][C:22]=1[F:23])[CH2:18][N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 5880883,4-DifluorobenzaldehydeHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2×

Product 1

HCID 136102563HCID 136102563, compound

Procedure

6-[4-(3,4-Difluoro-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure A from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 3,4-difluorobenzaldehyde. Mass spectrum (ES) MH+=307.

Sources & evidence

ORD record
ord-b8e1c455346847e5a73d9a08f91554ff
Source dataset
uspto-grants-2010_01
Patent number
US07652013B2

Reaction notes

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