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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993427Generated: October 31, 2026

2-Chloro-5-(trifluoromethyl)benzaldehyde → 6-[4-(2-Chloro-5-trifluoromethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one

https://huagongshe.com/reaction/1993427

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-(trifluoromethyl)benzaldehydeHCID 688181—
Reactant6-piperazin-1-yl-3H-pyrimidin-4-oneHCID 136102540—
Product6-[4-(2-Chloro-5-trifluoromethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-oneHCID 136102538—

Reaction Steps

6-[4-(2-Chloro-5-trifluoromethyl-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure A from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2-chloro-5-(trifluoromethyl)benzaldehyde. Mass spectrum (ES) MH+=373.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07652013B2
Source datasetuspto-grants-2010_01
ORD IDord-2b3eccfdad7144eba4c40f5439eb5222
Source noteuspto-grants-2010_01