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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993435Generated: October 25, 2026

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde → 6-[4-(2-Hydroxy-5-trifluoromethoxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one

https://huagongshe.com/reaction/1993435

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Hydroxy-5-(trifluoromethoxy)benzaldehydeHCID 1268058—
Reactant6-piperazin-1-yl-3H-pyrimidin-4-oneHCID 136102540—
Product6-[4-(2-Hydroxy-5-trifluoromethoxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-oneHCID 135879445—

Reaction Steps

6-[4-(2-Hydroxy-5-trifluoromethoxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure A from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2-hydroxy-5-trifluoromethoxybenzaldehyde. Mass spectrum (ES) MH+=371.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07652013B2
Source datasetuspto-grants-2010_01
ORD IDord-7f12bbe046e54c999c77bb70cdc06928
Source noteuspto-grants-2010_01