3-Methylsalicylaldehyde → HCID 136102585, compound

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Reaction Steps

6-[4-(2-Hydroxy-3-methyl-benzyl)-piperazin-1-yl]-3H -pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2-hydroxy-3-methylbenzaldehyde (available from Aldrich). 1H NMR (400 MHz, CDCl3) δ 2.25 (s, 3H), 2.58-2.63 (m, 4H), 3.48-3.63 (m, 4H), 3.71 (s, 2H), 5.39 (s, 1H), 6.69-6.73 (m, 1H), 6.82-6.83 (m, 1H), 7.05-7.07 (m, 1H), 7.84 (s, 1H), 10.60 (br s, 1H), 12.60 (br s, 1H). Mass spectrum (ES) MH+=301.

Provenance & Evidence