5-Fluorosalicylaldehyde → HCID 136102565, compound

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6-[4-(5-Fluoro-2-hydroxy-benzyl)-piperazin-1-yl]-3H -pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 5-fluoro-2-hydroxybenzaldehyde (available from Aldrich). 1H NMR (400 MHz, DMSO-d6) δ 2.45-2.48 (m, 4H), 3.43-3.49 (m, 4H), 3.57 (s, 2H), 5.28 (s, 1H), 6.73-6.80 (m, 1H), 6.89-6.94 (m, 1H), 6.99-7.02 (m, 1H), 7.89 (s, 1H), 9.90 (br s, 1H), 11.64 (br s, 1H). Mass spectrum (ES) MH+=305.

Provenance & Evidence