反应详情

6-[4-(3-Chloro-2-hydroxy-benzyl)-piperazin-1-yl]-3H -pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 3-chloro-2-hydroxybenzaldehyde (available from Aldrich). 1H NMR (400 MHz, DMSO-d6) δ 3.50-3.58 (m, 4H), 3.79 (s, 2H), 5.29 (s, 1H), 6.76-6.80 (m, 1H), 7.04-7.06 (m, 1H), 7.27-7.29 (m, 1H), 7.90 (s, 1H), 11.66 (br s, 1H). Mass spectrum (ES) MH+=321.