4-(N-Boc-amino)piperidine → tert-Butyl 1-[4-(aminocarbonyl)-6-chloropyridin-2-yl]piperidin-4-ylcarbamate

HRID 199345Notes

Reaction equation

HRID 199345 reaction equation
[CH3:26][N:27]([CH:28]([CH:29]([CH3:30])[CH3:31])[CH3:32])[CH3:33].[Cl:15][c:16]1[cH:17][c:18]([C:19](=[O:20])[NH2:21])[cH:22][c:23]([Cl:25])[n:24]1.[NH:1]1[CH2:2][CH2:3][CH:4]([NH:7][C:8]([O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[CH2:5][CH2:6]1>>[N:1]1([c:23]2[cH:22][c:18]([C:19](=[O:20])[NH2:21])[cH:17][c:16]([Cl:15])[n:24]2)[CH2:2][CH2:3][CH:4]([NH:7][C:8]([O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 7238334-(N-Boc-amino)piperidineHCID 27818022,6-DichloroisonicotinamideHCID 22949790N,N,3-Trimethylbutan-2-amine

Product 1

HCID 86608240tert-Butyl 1-[4-(aminocarbonyl)-6-chloropyridin-2-yl]piperidin-4-ylcarbamate

Sources & evidence

ORD record
ord-7c06a59f8eb04633bff40e9b79f57072
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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