3-Bromo-2-hydroxybenzaldehyde → HCID 136102546, compound

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Reaction Steps

6-[4-(3-Bromo-2-hydroxy-benzyl)-piperazin-1-yl]-3H -pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 3-bromo-2-hydroxybenzaldehyde (available from Aldrich). 1H NMR (400 MHz, CDCl3) δ 2.62-2.66 (m, 4H), 3.60-3.70 (m, 4H), 3.75 (s, 2H), 5.40 (s, 1H), 6.67-6.70 (m, 1H), 6.92-6.94 (m, 1H), 7.43-7.45 (m, 1H), 7.84 (s, 1H), 11.95 (br s, 1H). Mass spectrum (ES) MH+=365.

Provenance & Evidence