HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dibromosalicylaldehyde → 6-[4-(3,5-Dibromo-2-hydroxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dibromosalicylaldehyde | HCID 7024 | — |
| Reactant | 6-piperazin-1-yl-3H-pyrimidin-4-one | HCID 136102540 | — |
| Product | 6-[4-(3,5-Dibromo-2-hydroxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one | HCID 136102555 | — |
Reaction Steps
6-[4-(3,5-Dibromo-2-hydroxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 3,5-dibromosalicylaldehyde (available from Aldrich). 1H NMR (400 MHz, CDCl3) δ 2.62-2.66 (m, 4H), 3.48 (s, 1H), 3.58-3.65 (m, 4H), 3.72 (s, 2H), 5.40 (s, 1H), 7.07 (s, 1H), 7.58 (s, 1H), 7.84 (s, 1H), 11.90 (br s, 1H). Mass spectrum (ES) MH+=445.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652013B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-b7dfb059035a442885a8a89e9128ec23 |
| Source note | uspto-grants-2010_01 |