5-allyl-2-hydroxy-3-methoxybenzaldehyde → HCID 136102551, compound

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6-[4-(5-Allyl-2-hydroxy-3-methoxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 5-allyl-2-hydroxy-3-methoxybenzaldehyde (available from Acros Organics, Geel, Belgium). 1H NMR (400 MHz, CDCl3) δ 2.58-2.63 (m, 4H), 3.27-3.29 (m, 2H), 3.58-3.65 (m, 4H), 3.71 (s, 2H), 3.91 (s, 3H), 5.03-5.08 (m, 2H), 5.39 (s, 1H), 5.88-5.95 (m, 1H), 6.43 (s, 1H), 6.65 (s, 1H), 7.84 (s, 1H), 10.40 (br s, 1H), 12.80 (br s, 1H). Mass spectrum (ES) MH+=357.

Provenance & Evidence