反应详情

6-[4-(5-Chloro-2-hydroxy-3-methoxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 5-chloro-2-hydroxy-3-methoxybenzaldehyde (available from Aldrich). 1H NMR (400 MHz, CDCl3) δ 2.50-2.55 (m, 4H), 3.60-3.66 (m, 4H), 3.70 (s, 2H), 3.88 (s, 3H), 5.39 (s, 1H), 6.61-6.62 (m, 1H), 6.80-6.81 (m, 1H), 7.84 (s, 1H), 12.40 (br s, 1H). Mass spectrum (ES) MH+=351.