HCID 59134395, compound → HCID 59134360, compound

HRID 1993484Notes

Reaction equation

HRID 1993484 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([O:11][C:12]([CH3:16])([CH3:15])[C:13]#[CH:14])[CH:8]=[CH:7][C:6]=1[N+:17]([O-:19])=[O:18]>ClC1C=CC=CC=1Cl>[CH3:1][O:2][CH2:3][O:4][C:5]1[C:6]([N+:17]([O-:19])=[O:18])=[CH:7][C:8]2[CH:14]=[CH:13][C:12]([CH3:15])([CH3:16])[O:11][C:9]=2[CH:10]=1

Participants

3

Reactant 1

HCID 59134395HCID 59134395, compound

Product 1

HCID 59134360HCID 59134360, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

A solution of 2-methoxymethoxy-4-(1,1-dimethyl-2-propynyloxy)-1-nitro-benzene (2.1 g, 7.92 mmol) in 1,2-dichlorobenzene (21 mL) was stirred at 20° C. for 0.5 hour. Upon the completion of the reaction, the resulting mixture was concentrated and purified by silica gel column (hexane/ethyl acetate=5/1). Thereby, a mixture (1:1) of the aimed product and the regioisomer was obtained (yield: 77%).

Workup

  1. customUpon the completion of the reaction
  2. concentrationthe resulting mixture was concentrated
  3. custompurified by silica gel column (hexane/ethyl acetate=5/1)

Sources & evidence

ORD record
ord-5a9ef30b60ea47c882d37951e21d9a84
Source dataset
uspto-grants-2010_01
Patent number
US07652008B2

Reaction notes

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