反应详情

温度

100 °C

To a solution of N-benzyl-5-methoxyisatin (3.0 g, 11.2 mmol) in dichloromethane (60 mL), aluminum chloride (3.7 g, 28.1 mmol) was added, and the resulting mixture was stirred at 100° C. for 1 hour. Water was added thereto, and the resulting solution was extracted with ethyl acetate. The resulting organic phase was washed with saturated aqueous sodium hydrogencarbonate solution and then with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated to obtain the aimed product (yield: 78%).

1. extractionthe resulting solution was extracted with ethyl acetate
2. washThe resulting organic phase was washed with saturated aqueous sodium hydrogencarbonate solution
3. dry with materialwith saturated sodium chloride solution, dried over anhydrous sodium sulfate
4. concentrationconcentrated