Methylamine → HCID 58659454, compound

Participants

Reaction Conditions

Reaction Steps

1-[4-(6-Chloro-pyrimidin-4-yloxy)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea (Example 56) (42.7 mg, 0.1 mmol) is dissolved in methylamine (30% in EtOH, 1 mL) in a sealable tube and heated under Ar for 10 min at 50° C. After evaporating the solvent, the product is purified by preparative TLC (2 20×20 cm plates, acetone/CH2Cl2=3:7) to give the title compound as a white solid: M+H=404.1; 1H-NMR (400 MHz, CDCl3): 8.22 (s, 1H, pyridinyl), 7.84 (s/broad, 1H, NH), 7.62 (s, 1H, 3-CF3-phenyl), 7.52 (d, 8.0 Hz, 1H, CF3-phenyl), 7.35 (t, 8.0 Hz, 1H, 3-CF3-phenyl), 7.28 (m, 3H, CF3-phenyl/oxo-phenyl-amine), 6.97 (d, 9.5 Hz, 2H, oxo-phenyl-amine), 5.62 (d/broad, 2H, pyridinyl), 5.44 (s/broad, 1H, NH), 2.89 (s/broad, CH3—N); Rf (acetone/CH2Cl2=3:7): 0.36.

Provenance & Evidence