Propan-2-one--dichloromethane (1/1) → HCID 58659368, compound

Participants

Reaction Steps

The title compound is synthesized in analogy to the preparation of compound of Example 48 starting from compound of Stage 56.1: M+H=423.1/M+18=440.1; Rf (CH2Cl2/acetone=9:1): 0.42; 1H-NMR (400 MHz, DMSO-d6): 8.93/8.80 (s/s, 2H, urea), 7.91 (d, 2 Hz, 1H, pyrimidinyl), 7.51 (d, 9.5 Hz, 2H, phenyl), 7.47 (d, 8.0 Hz, 1H, phenyl-CF3), 7.29 (d, 8 Hz, 1H, phenyl-CF3), 7.27 (s, 1H, phenyl-CF3), 7.13 (d, 9.5 Hz, 2H, phenyl), 4.08 (m, 1H, pyrimidinyl), 2.63 (s/broad, 3H, CH3); m.p.=183.0-184.5° C.

Provenance & Evidence