Water → HCID 58659338, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of N-(4-(6-methoxy-pyridin-3-ylmethyl)-phenyl)-N′-(4-methyl-phenyl)-urea (Example 95; 0.28 g, 0.81 mmol) and trimethylsilyl-jodide (0.6 ml) in chloroform (10 ml) is stirred for 16 h at 60° C. Then CH2Cl2 (4 ml), water (10 ml) and saturated NaHCO3 solution (5 ml) is added and the suspension stirred vigorously. Filtration, washing with CH2Cl2 and water followed by column chromatography (SiO2; AcOEt/MeOH 9:1→4:1 MeOH) yields the title compound: 1H-NMR (DMSO-d6): 11.4 (s, HN), 8.52 (s, HN), 8.47 (s, HN), 7.33 (d, 2H), 7.29 (d, 2H), 7.25 (dd, 1H), 7.16 (s, 1H), 7.07 (d, 2H), 7.04 (d, 2H), 6.24 (d, 1H), 3.58 (s, 2H), 2.22 (s, 3H).

Provenance & Evidence