4-Ethylphenyl isocyanate → 1-(4-Ethyl-phenyl)-3-[4-(2-trifluoromethyl-pyridin-4-yloxy)-phenyl]-urea

HRID 1993543Notes

Reaction equation

HRID 1993543 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH:6]=[CH:5][N:4]=1.[CH2:19]([C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1)[CH3:20]>>[CH2:19]([C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([NH:16][C:13]2[CH:14]=[CH:15][C:10]([O:9][C:7]3[CH:6]=[CH:5][N:4]=[C:3]([C:2]([F:1])([F:17])[F:18])[CH:8]=3)=[CH:11][CH:12]=2)=[O:29])=[CH:23][CH:22]=1)[CH3:20]

Participants

3

Reactant 2

HCID 900074-Ethylphenyl isocyanateHCID 591345604-{[2-(Trifluoromethyl)pyridin-4-yl]oxy}aniline

Product 1

HCID 586593991-(4-Ethyl-phenyl)-3-[4-(2-trifluoromethyl-pyridin-4-yloxy)-phenyl]-urea

Procedure

The title compound is prepared as described in Example 102 but using 4-(2-trifluoromethyl-pyridin-4-yloxy)-phenylamine (Example 108) and 4-ethyl-phenyl-isocyanate. The reaction mixture is stirred for 4.5 h. The title compound is obtained as a white solid: ES-MS: 401.9 [M+H]+; single peak at tR=9.33 min (System 2); Rf=0.37 (CH2Cl2/Et2O, 90/10).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-aabc1f9a26e4435682c0b7bb876c47b4
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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