4-Ethylphenyl isocyanate → 1-(4-Ethyl-phenyl)-3-[4-(6-Fluoro-pyrimidin-4-yloxy)-phenyl]-urea

HRID 1993546Notes

Reaction equation

HRID 1993546 reaction equation
[F:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH:3]=1.[CH2:16]([C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1)[CH3:17]>>[CH2:16]([C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25]([NH:15][C:12]2[CH:13]=[CH:14][C:9]([O:8][C:4]3[CH:3]=[C:2]([F:1])[N:7]=[CH:6][N:5]=3)=[CH:10][CH:11]=2)=[O:26])=[CH:20][CH:19]=1)[CH3:17]

Participants

3

Reactant 2

HCID 900074-Ethylphenyl isocyanateHCID 586594294-(6-Fluoropyrimidin-4-yloxy)benzenamine

Product 1

HCID 586593501-(4-Ethyl-phenyl)-3-[4-(6-Fluoro-pyrimidin-4-yloxy)-phenyl]-urea

Procedure

The title compound is prepared as described in Example 102 but using 4-(6-fluoro-pyrimidin-4-yloxy)-phenylamine (Example 111) and 4-ethyl-phenyl-isocyanate. The reaction mixture is stirred for 4 h. The title compound is obtained as a white solid: ES-MS: 353.0 [M+H]+; single peak at tR=8.61 min (System 2); Rf=0.14 (CH2Cl2/Et2O, 90/10).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-7149ff6e050c4d5c9521ed7787467611
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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