HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenyl isocyanate → 1-[4-(6-Fluoro-pyrimidin-4-yloxy)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenyl isocyanate | HCID 9483 | — |
| Reactant | 4-(6-Fluoropyrimidin-4-yloxy)benzenamine | HCID 58659429 | — |
| Product | 1-[4-(6-Fluoro-pyrimidin-4-yloxy)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea | HCID 58659409 | — |
Reaction Steps
The title compound is prepared as described in Example 102 but using 4-(6-fluoro-pyrimidin-4-yloxy)-phenylamine (Example 111) and α,α,α-trifluoro-m-tolyl-isocyanate. The reaction mixture is stirred for 4 h. The title compound is obtained as a white solid: ESMS: 392.9 [M+H]+; single peak at tR=8.90 min (System 2); Rf=0.14 (CH2Cl2/Et2O, 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652022B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-5ba0289adc034c95b613c6fc5a1cd320 |
| Source note | uspto-grants-2010_01 |