3-(Trifluoromethyl)phenyl isocyanate → 1-(3-Trifluoromethyl-phenyl)-3-[4-(6-trifluoromethyl-pyrimidin-4-yloxy)-phenyl]-urea

HRID 1993550Notes

Reaction equation

HRID 1993550 reaction equation
[C:1]1(C)[CH:6]=[CH:5][C:4]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[N:21]=[CH:20][N:19]=3)=[CH:13][CH:12]=2)=[O:9])=[CH:3][CH:2]=1.[F:29][C:30]([F:41])([F:40])C1C=CC=C(N=C=O)C=1>>[F:29][C:30]([F:41])([F:40])[C:6]1[CH:5]=[C:4]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:23]=[C:22]([C:24]([F:27])([F:25])[F:26])[N:21]=[CH:20][N:19]=3)=[CH:13][CH:12]=2)=[O:9])[CH:3]=[CH:2][CH:1]=1

Participants

3

Reactant 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 586593391-p-Tolyl-3-[4-(6-trifluoromethyl-pyrimidin-4-yloxy)-phenyl]-urea

Product 1

HCID 586593601-(3-Trifluoromethyl-phenyl)-3-[4-(6-trifluoromethyl-pyrimidin-4-yloxy)-phenyl]-urea

Procedure

The title compound is prepared as described in Example 102 but using 4-(6-trifluoromethyl-pyrimidin-4-yloxy)-phenylamine (Example 114) and α,α,α-trifluoro-m-tolyl-isocyanate. The reaction mixture is stirred for 2.5 h. The title compound is obtained as a white solid: ES-MS: 442.9 [M+H]+; single peak at tR=9.83 min (System 2).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-f351e00fe66349cc8a94cedba35a2497
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

Loading…