4-Ethylphenyl isocyanate → HCID 58659421, compound

HRID 1993558Notes

Reaction equation

HRID 1993558 reaction equation
[CH3:1][NH:2][C:3]1[N:8]=[CH:7][N:6]=[C:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)=[O:18])=[CH:12][CH:11]=2)[CH:4]=1.[CH2:27](C1C=CC(N=C=O)=CC=1)C>>[CH2:26]([C:23]1[CH:22]=[CH:21][C:20]([NH:19][C:17]([NH:16][C:13]2[CH:12]=[CH:11][C:10]([CH2:9][C:5]3[CH:4]=[C:3]([NH:2][CH3:1])[N:8]=[CH:7][N:6]=3)=[CH:15][CH:14]=2)=[O:18])=[CH:25][CH:24]=1)[CH3:27]

Participants

3

Reactant 2

HCID 900074-Ethylphenyl isocyanateHCID 58659402HCID 58659402, compound

Product 1

HCID 58659421HCID 58659421, compound

Procedure

The title compound Is prepared as described in Example 102 but using [6-(4-amino-benzyl)-pyrimidin-4-yl]-methyl-amine (Example 119) and 4-ethyl-phenyl-isocyanate. The reaction mixture is stirred for 6 h. The title compound is obtained as a white solid: ES-MS: 362.0 [M+H]+; single peak at tR=7.14 min (System 2).

Workup

  1. customThe title compound Is prepared

Sources & evidence

ORD record
ord-4eb230831ac540ecb47c3da3437cbd43
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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