3-(Trifluoromethyl)phenyl isocyanate → HCID 178522230, compound

Participants

Reaction Steps

The title compound is prepared as described in Example 102 but using 4-[2-(1H-tetrazol-5-yl)-pyridin-4-yloxy]-phenylamine and α,α,α-trifluoro-m-tolyl-isocyanate. The reaction mixture is stirred for 4 h. The crude product Is washed with a solution of CH2Cl2/MeOH (95/5) and dried In vacuo to afford the title compound as a beige solid: ES-MS: 441.9 [M+H]+; single peak at tR=7.93 min (System 2); Rf=0.36 (CH2Cl2/MeOH, 80/20).

Provenance & Evidence