HCID 58659356, compound → HCID 58659362, compound

Participants

Reaction Steps

Hydrogenation of N-(4-(4-azidopyrimidin-6-yl-oxy)-phenyl)-N′-(3-trifluoromethyl-4-(piperidin-1-ylmethyl)-phenyl)-urea (Example 130; 213 mg, 0.41 mmol) in the presence of 10% Pd/C (40 mg) in 10 ml of THF during 2 h at rt, filtration and concentration of the filtrate affords the title compound: MS: [M+1]+=487; 1H-NMR (DMSO-d6): 9.09 & 8.92 (2s, 2HN), 8.03 & 7.93 (2s, 2H), 7.69 & 7.65 (2m, 2H), 7.47 & 7.03 (2d, 2×2H), 6.79 (s, 2H), 5.6 (s, 1H), 3.46 (s, 2H), 2.31 (m, 4H), 1.49 (m, 4H), 1.40 (m, 2H).

Provenance & Evidence