HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propan-2-one--dichloromethane (1/1) → [6-(4-Amino-2-methyl-phenoxy)-pyrimidin-4-yl]-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| Reactant | [3-Methyl-4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-carbamic acid benzyl ester | HCID 68537615 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | [6-(4-Amino-2-methyl-phenoxy)-pyrimidin-4-yl]-methyl-amine | HCID 68537196 | — |
Reaction Steps
The title compound is prepared from [3-methyl-4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-carbamic acid benzyl ester by hydrogenation in the presence of Pd/C in MeOH/THF: M+H=230.9; Rf (acetone/CH2Cl2=1:1): 0.20.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652022B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-0cada57be2d34d56b70d25b97fecebc7 |
| Source note | uspto-grants-2010_01 |