反应详情

A suspension of [4-(6-azido-pyrimidin-4-ylmethyl)-phenyl]-carbamic acid tert-butyl ester (870 mg, 2.66 mmol) and 10% Pd/C (174 mg) in MeOH (35 mL) is stirred for 1.5 h at rt and a hydrogen atmosphere. The reaction mixture is filtered through a plug of celite (washing the filter cake with copious amounts of MeOH). The filtrate is concentrated in vacuo to afford the title compound as a beige solid: ES-MS: 301.1 [M+H]+; single peak at tR=6.25 min (System 2).

1. filtrationThe reaction mixture is filtered through a plug of celite (
2. washwashing the filter cake with copious amounts of MeOH)
3. concentrationThe filtrate is concentrated in vacuo